|
10/9/2019 6:57:48 AM
|
|
High Quality 99% Cetilistat Powder Price
|
High Quality 99% Cetilistat Powder Price
What is Cetilistat ?
Cetilistat is a White powder, it's CAS Number is 282526-98-1, it's MF is C25H39NO3.
Cetilistat powder is different from other anti-obesity drugs because instead of acting on the brain to decrease appetite.
Cetilistat works on the gastrointestinal tract to block fat absorption. Cetilistat is used to treat obesity and associated diseases like diabetes.
Functions and Traits of Cetilistat
Cetilistat is generally taken with food, or even up to 1 hour after having food. If you skip a meal or if your food does not contain any fat, you can skip taking Cetilistat for that meal. The exact dosage and period of treatment will depend on your specific diagnosis and overall health and will be prescribed by your doctor.
The most common side effects of Cetilistat are oily stool, increase bowel movements, diarrhoea, excessive gas, flatulence with oily discharge, and cramps in the abdomen. It may interfere with the absorption of fat soluble vitamins like vitamin A, D, E and K and thus may require additional supplements to be taken to make up for the deficiency.
Application of Cetilistat
Cetilistat is used to treat obesity and associated diseases like diabetes. It is administered along with a healthy low fat nutritious diet, abundant exercise.
Cetilistat is a lipase inhibitor and works by binding to and blocking the action of the enzyme lipase. This prevents the fat (triglycerides) in food from being metabolised and turned into free fatty acids that can be absorbed by the body. Instead, the un-metabolised fat is eliminated from the body through bowel movements.
|
|
10/15/2019 9:38:02 AM
|
|
Unique Tungsten Ring Inlays
|
Unique Tungsten Ring Inlays
Coming in all different shapes, materials and sizes, jewelry offers us many choices. While the European war did not officially start until the 1st September 1939 with the invasion of Poland simultaneously made by Germany and the Soviet Union, the Second World war began much earlier in Asia and Africa with the Italian invasion of Ethiopia in 1936 and the Japanese invasion of China in 1937.Full Arc Tungsten Rings women
Also, tungsten also does not lose its color like white gold does after a short time of wear. Within a few days, Britain and France declared war on Germany and began mobilizing their armies while at the same time preparing shelters for their civilians from the arrogant Nazis.
French in 1940 had more tanks than Germany. The nation was liberated during 1941 by British forces, led by Colonel Orde Wingate after who's success, on the 5th May 1941, Emperor Haile Selassie was returned to the throne after his enforced exile. Possibly 300,000 innocent Chinese civilians living in Nanking were raped and executed by the bloodthirsty Japanese occupation force within one month.
The involvement of the British Colony of Kenya in the Second World War began with the declaration of war on Nazi Germany by the British Empire in September 1939. On 13th Oct 1943, the government of Italy declared war on its former Axis partner Germany and joined the battle on the side of the Allies.
The only problem is that with all the wedding rings options available, how can one decide which fits the your active lifestyle best while at the same time saves you some scratch for that crazy hobby craft of yours. During World War II almost 30,000 troops from Nyasaland served in the British armed forces.
Following Pearl Harbour the Dominican Republic declared war on Japan on 8th December 1941 and war on Germany on 11th December 1941. Whether you're looking for a platinum inlay with embedded diamonds or a simple polished ring, tungsten carbide rings of great quality are out there waiting for you.
It joined the war on 4th September 1939, declaring war on Germany. Nepal declared war on Germany on 4th September 1939 and provided the much-feared and very capable Gurkha soldiers to Britain, who used them to great effect. If when you're searching for a wedding band and assumed you could find nothing other than the traditional silver, gold and platinum, well, you'd be wrong.
So in a sense, tungsten rings are "permanently polished", as their durability holds up and stands up to the test of time. Black tungsten rings are made by heating up the tungsten metal and plating the ring with the coloring. Tungsten, aside from being popular for use in the jewelry industry, has many more characteristics that make this metal ideal for many things.
|
|
10/15/2019 9:42:22 AM
|
|
Tungsten Carbide Weddings Rings
|
Tungsten Carbide Weddings Rings
There is a rage among the youth to buy tungsten rings these days. In the early days of the war, the Allies demanded that Iran remove influential German nationals from Iran fearing they might be Nazi spies or intentionally harm the supply of British owned oil but, Reza Shah refused stating that they had nothing to do with the Nazis.
There are some jewelers who used to claim that the tungsten wedding rings they offer is processed with a nickel but in fact it is mixed with a cobalt. Many retailers claim to have quality tungsten rings, but you must make sure that you are getting true tungsten carbide rings.tungsten wedding bands for him and her
Tungsten is about 10 times harder than 18K Gold, 5 times harder than tool steel, and 4 times harder than titanium. After this initial war, Finland sought security and support from Sweden and Britain but was thwarted by Soviet threats and German actions. This hardness means palladium rings are much more pure than other metals used in jewelry.
On 30th September 1938, to their chagrin, Adolf Hitler, Benito Mussolini, French Premier Edouard Daladier, and British Prime Minister Neville Chamberlain signed the Munich Pact, concerning Czechoslovakia, which virtually handed part of the country over to Germany in the, so called, name of peace.
A tungsten carbide ring never needs to be re-polished, even years or decades after you own it, which means you never have to spend any money on re-polishing of your ring, as is the case with precious metal rings. In 1944, Portugal declared a total embargo of tungsten to Germany.
The Turks allowed the passage of thousands of Jewish refugees to Palestine at a time that both the Germans and British attempted to prevent this, but for very different reasons. When this dense, durable metal is combined with carbon alloy to make tungsten carbide, one has the material to make gorgeous and enduring jewelry.
|
|
10/15/2019 9:45:50 AM
|
|
Palm Tungsten W Specs
|
Palm Tungsten W Specs
By now you have undoubtedly heard the term "tungsten" - albeit, usually by the term "tungsten carbide". On the other hand, the price of the carbide tungsten ring would likely the same with the platinum or gold. Estonia was occupied under German Operation Barbarossa in 1941 after war broke out between Germany and the Soviet Union. Tungsten rings consist of 85% tungsten carbide, which is the ideal tungsten carbide purity level to produce the strongest rings.tungsten rings in gold
The leftist administration of President Rafael Ángel Calderón Guardia was hostile to Nazism and declared war on Japan the day after the attack on Pearl Harbour, and on Germany and Italy shortly afterwards. During World War II, 4,000 Argentines served with all three British armed services, even though Argentina was officially a neutral country during the war.
He refused once again and in August 1941, the British, Indian and Soviet troops invaded Iran (Operation Countenance) and in September 1941, forced Reza Shah Pahlavi to abdicate his throne. From a total of 140,000 Dutch Jews, only 30,000 would survive the German occupation, murder and the war.
Tungsten carbide on the other hand is very durable and will last for a very long time, possibly generations even. India also provided the Allies with assault and training bases and provided huge quantities of food and other materials to British and Commonwealth forces, and to people on the British home front.
The only suitable metal object I could find was a preserving pan, where I could cut a six inch hole in the bottom and use the disc I cut out at the deflector at the top for the beauty dish and spray-painting the insides with silver car spray-paint for the reflective surface.
With the demise of Italy, whose surrender was announced on 8th September 1943, Germany and Japan each functioned as wholly separate powers, each conducting the war in their own particular theatre (Germany in Europe, Africa, America and Japan in the Pacific).
French fighters sent out on patrols to intercept German aircraft could do nothing else than simply fly a sortie along the sky and hope that they encountered a German fighter unit: a good intercept rate would be akin to 30 to 40% of the time the enemy being encountered.
Historically in 1940 the French were plagued by an incapability to command the fighters they had, to respond to German raids, and to mass their forces. These were the only British Commonwealth soldiers to be executed for mutiny during the Second World War. Men's tungsten wedding rings have become so popular women are jumping on the bandwagon as well.
|
|
10/15/2019 9:51:13 AM
|
|
Grade Alpha GPC Nootropics Powder
|
Grade Alpha GPC Nootropics Powder
Alpha-GPC is a choline-containing supplement that, although found in a variety of food products that are also rich in choline, appears to be pharmacologically active at higher doses.
Alpha-GPC is mostly marketed due to it conferring dietary choline to the body following oral ingestion, and being the most efficient choline prodrug at doing so (able to influence both systemic and brain concentrations of choline).Nootropics powder
Due to the provision of the other half of the alpha-GPC molecule (glycerophosphate), alpha-GPC also appears to support the structure of cellular membranes, which is not a common mechanism attributed to choline prodrugs (only CDP-choline is associated with lipid membranes in this sense).
Alpha-GPC is of interest for nootropic purposes, as it appears to have cognitive-enhancing properties and attenuate the rate of cognitive decline in the elderly. In regards to reducing the rate of cognitive decline, alpha-GPC at high doses (1,200 mg) does appear to be somewhat effective in mild to moderate Alzheimer's disease and works nicely with the standard therapy (acetylcholinesterase inhibitors).
Athletes are at times interested in alpha-GPC due to its ability to enhance growth hormone production (of which only acute spikes have been reported so far, so it may fall to the same problems that arginine has on growth hormone) and to enhance power output, which has a lone pilot study in support of 600 mg alpha-GPC prior to exercise.
Alpha-GPC Dose:
1 .A standard dosage of alpha-GPC is 300-600 mg.
2. For the usage of alpha-GPC in attenuating symptoms of cognitive decline, almost all studies use a dosage of 1,200 mg daily, divided into three doses of 400 mg.
|
|
10/15/2019 9:55:38 AM
|
|
Nootropics Powder 6-Parado 50% Powder
|
Nootropics Powder 6-Parado 50% Powder
The 6-Paradol, with the CAS registry number 27113-22-0, is also known as 3-Decanone, 1-(4-hydroxy-3-methoxyphenyl)-. Its EINECS registry number is 248-228-1. This chemical's molecular formula is C17H26O3 and molecular weight is 278.38654. What's more, its IUPAC name is 1-(4-Hydroxy-3-methoxyphenyl)decan-3-one. This chemical's classification code is Drug / Therapeutic Agent. In addition, 6-Paradol is the active flavor constituent of the seeds of Guinea pepper (Aframomum melegueta). And the seed is also known as Grains of paradise. Besides, this chemical has been found to have antioxidative and antitumor promoting effects. And it is used in flavors as an essential oil to give spiciness.Paradol is the active flavor constituent of the seeds of Guinea pepper (Aframomum melegueta). Theseed is also known as Grains of paradise. Paradol has been found to have antioxidative andantitumor promoting effects.Best Nootropics powder
1.Weight loss
In a related clinical trial, researchers of the Japanese Society of Nutrition have found that aframomum melegueta has the ability to lower body fat percentage, and decreased waisthip ratio without any harmful side effects. Recently, further studies on
aframomum melegueta have reported its 6 paradol chemical constituent to be biologically significant beyond its medicinal value.
2. Bodybuilding benefits
Aframomum melegueta extract has been established to be beneficial in bodybuilding purposes as it obtains intense anti-estrogenic properties and promotes an increase in body weight and levels in serum by more than 300%.
3. Increase t level as a Aphrodisiac
This benefit of aframomum melegueta is not proofed by the scitific evidences. But many guys believe it works when take a few weeks
|
|
10/15/2019 10:00:59 AM
|
|
Best 10 Nootropic Supplements of 2019
|
Best 10 Nootropic Supplements of 2019
Nootropics, also known as smart drugs are an increasingly popular form of supplement that targets the mind rather than the body. They are known as cognitive enhancers, if you’ve ever seen the film “Limitless” then you have a rough idea of what they are designed to do. You can also read our post about noopept in bodybuilding supplements – what you should know.Best Nootropics powder
Sadly, no Nootropic is as effective as the made up drugs in the film, but there still are a lot of supplements out there that can help improve mood, focus, memory, and decision-making.
In this article we are going to take a look at ten of the best Nootropics out on the market today. We’ll assess their effectiveness, and whether they have the ingredients to match their proposed benefits.
1.NCN SUPPS: SHREDDEREX (PREV SHREDDERALL)
Shreddrex is a seriously loaded nootropic, designed to give you amazing mental focus while containing ingredients to help you burn fat as well. The formula is designed to get you in the zone, elevate your mood and increase your body’s metabolic rate. This formula was put together perfectly to help you get in the zone and energized, but not get you too stimmed. It doesn’t have any appetite suppressants like fat burners do, but definitely has a thermogenic effect. At 1 capsule, this is a kick ass nootropic very strong mental focus and energy, and just all around an amazing focus experience. The tub contains 60 pills and since I believe 1 pill is the best dose to achieve that awesome experience, this has 60 servings which adds great value for money. Definitely the best nootropic out there when you are looking for a kick for your buck.
2. MUSCLEFORCE: GRIND
This is a super strong nootropic that puts the emphasis on mood elevation, focus enhancement, brain boosting and energy. The label shows 2-4 capsules ratio, and I found 4 capsules too much for me mainly because of the caffeine, and 2 capsules were a bit too little. HOWEVER – with 3 capsules, it was magic. This nootropic gets you in the zone in a really good way, energized but not jittery, and the best part is for sure the mood elevation. You just feel good. It gets you going even in doing things you don’t like doing. At 3 capsules the effects last a really long time, so I wouldn’t recommend taking it close to bed time. All things considered, this is one of the best nootropics supplements in the market.
3. FITNESS STACKS: HYPER STACK
HyperStack’s formula has a hefty dose of mood elevation and focus stimulants. With noopept at 40mg and 2mg of Alpha Yo for 1 (!) scoop, you can be sure it is a strong af formula. This nootropic doesn’t have a lot of caffeine, but is definitely strong on the other stims. This is a hype nootropic, on the verge of a pre-workout, and gets you seriously hyped. If you try 2 capsules you would probably feel it too strongly. The use case for this crazy strong nootropic, for me at least, is when you’re extremely tired and really need a serious boost of energy, mood elevation and mental focus. At 2 capsules you will definitely feel stimmed, perhaps over-stimmed, but at 1 capsule I found this to be a great product to help with get stuff done when I was extremely tired.
4. MYPROTEIN: THE NEURO ENGAGE
This nootropic is the best choice for an afternoon focus and energy enhancement. With L-Theanine in the formula, it really helps the effects fade out smoothly and doesn’t keep you up too long. This product will not get you going crazy and jittery with energy, but will definitely get you feeling more dialed-in. If you want to study or work and just be in the zone and focused for a few hours this is a solid formula, that fades away pretty quick and makes it perfect for the afternoon use cases. The experience was good for the time it lasted and got me focused and doing what I needed to do, without keeping me awake when it was bedtime.
|
|
10/15/2019 10:05:57 AM
|
|
NOOTROPICS CASE STUDY: A SOOTHING COMPOUND CALLED
|
NOOTROPICS CASE STUDY: A SOOTHING COMPOUND CALLED PHENIBUT
Most people take good care of their physical health and fitness, or at least they try to. Mental wellness, on the other hand, is often neglected and many early signs of mental disorders are overlooked until the problem gets too serious to ignore.nootropics
The good news is that there is increasing recognition of mental disorders and the importance of mental health in our stress-loaded present-day lifestyle. Consequently, there is increasing interest in products and supplements that are intended to improve mental well-being.
Nootropics are a hot topic right now. Don’t worry if you’ve never heard the word “nootropic” before — this is simply a fancy term for any supplement or drug that is used to enhance aspects of cognitive performance. For example, caffeine improves alertness and concentration, thus it is considered a nootropic substance.
There are probably hundreds of different nootropic substances on the market, consisting of both natural extracts and synthetic compounds. They can be categorized based on their primary uses, and one of the most sought-after types of nootropics are those used to support relaxation and restful sleep.
Anxiety and stress can dramatically hinder cognitive abilities during the day. Additionally, anxiety can make it impossible to get adequate sleep at night, which also contributes towards poor cognitive performance.By reducing the levels of anxiety and stress and promoting better sleep quality, some nootropics can make a big improvement in some people’s lives. Phenibut is one of those nootropics and we are going to learn a little bit more about this common anti-anxiety aid and its benefits.
Phenibut is the commercial name for the compound 4-amino-3-phenylbutyric acid. This is a synthetic analogue of an amino acid called GABA — short for gamma aminobutyric acid.GABA is an inhibitory neurotransmitter in the brain that is responsible for inhibiting stimulation and inducing a state of rest and tranquility.
Since phenibut is structurally similar to GABA, it binds to GABA receptors in brain cells and causes them to calm and slow down. In other words, phenibut is effectively GABA, but it has greater effectiveness at lower concentrations.
Phenibut has strong anxiety-reducing and sedative properties, and it is mainly used for people who suffer from anxiety, nervousness and insomnia. In a few countries, it is an approved treatment option for some disorders, however, in the USA it is not approved by the FDA, but it is available as an over-the-counter supplement.
|
|
10/15/2019 10:09:01 AM
|
|
CRN issues voluntary guidelines on SARMs
|
CRN issues voluntary guidelines on SARMs
In light of growing concerns on the dangers of products containing selective androgen receptor modulators (SARMs) and caffeine-containing dietary supplements, the Council for Responsible Nutrition announced on Thursday that it has issued new voluntary guidelines.RAD140 powder
“CRN’s membership is committed to consumer safety and understands the gravity of going above and beyond what is required by law to ensure their products are high-quality, consistent, and supported by sound science,” said Steve Mister, president and CEO of CRN. “Consumer access to bulk amounts of highly-concentrated powder or liquid caffeine and performance enhancing products containing SARMs are current subjects of sharp industry scrutiny. CRN is grateful for FDA’s recent consumer advisories on these ingredients, as well as for guidance providing clarity to companies attempting to navigate the industry’s strict regulatory framework. CRN’s voluntary guidelines align with FDA’s enforcement actions and help the dietary supplement industry stay on the right side of the law.”
The newly developed guidelines for products containing SARMs stem from increasing concerns raised by FDA, the U.S. Anti-Doping Agency, and the legitimate dietary supplement industry about the dangers of SARMs found in products mis-marketed as dietary supplements. Among the challenges the industry faces with respect to SARMs is the introduction of substances that do not appear to meet the definition of a dietary ingredient as outlined by the United States Federal Food, Drug, and Cosmetic Act; fail to provide proper notification to FDA as new dietary ingredients (NDI); and appear to lack scientific evidence supporting safety, CRN stated. Coinciding with FDA’s position that products containing SARMs do not meet the definition of a dietary supplement, CRN’s guidelines recommend that firms should not distribute or market products containing these ingredients.
CRN’s guidelines for caffeine-containing dietary supplements, originally created in 2013, recommend that companies disclose the amount of caffeine in a dietary supplement, provide label advisories about safe use of such products, and refrain from sale under certain conditions. The guidelines were updated in 2015 to institute restraints against the sale and marketing of bulk amounts of pure or highly-concentrated caffeine in powder form, and the 2018 revisions expand these restraints to also include concentrated liquid forms, as outlined by an FDA guidance released earlier this year.
“CRN trusts that the dietary supplement industry will adopt these two sets of crucial guidelines into its standard operating procedures,” said Mister. “As the marketplace continues to grow and innovate, we lend our full support to FDA’s proactive enforcement efforts to improve consumer safety and industry accountability.
|
|
10/15/2019 10:12:43 AM
|
|
High quality MK 677 sarms powder
|
High quality MK 677 sarms powder
1. Product Name:High quality MK 677 Sarms powder
2. M.F.: C28H40N4O8S2
3. Appearance:White powder
4. Molecular Weight: 624.769
5. CAS Number: 159752-10-0
6. Test Method: HPLC
7. Introduction:
Ibutamoren (MK-677, L-163,191) is a drug which acts as a potent, orally active growth hormonesecretagogue, mimicking the GH stimulating action of the endogenous hormone ghrelin. It has been demonstrated to increase the release of, and produces sustained increases in plasma levels of several hormones including growth hormone and IGF-1, but without affecting cortisol levels. It is currently under development as a potential treatment for reduced levels of these hormones, such as in growth hormone deficient children or elderly adults, and human studies have shown it to increase both muscle mass and bone mineral density, making it a promising therapy for the treatment of frailty in the elderly. It also alters metabolism of body fat and so may have application in the treatment of obesity.
|
|
10/15/2019 10:15:38 AM
|
|
New Batch Best Sarms SR9009 Powder Hot sale
|
New Batch Best Sarms SR9009 Powder Hot sale
The optimal dosages range from 20 to 30 milligrams (mgs) per day. However, there is one drawback – due to a very short half life, you will need to space it out throughout the day for the best balance of the active substance in the body. Thus, it is best to use stenabolic every 2-4 hours, depending on the exact dosage used. For example, when the daily dosage is 30 mgs, you can take 10 mgs every 4 hours.Best Sarms Powder
New Batch Best Sarms SR9009 Powder
Up to now, no side effects have been observed with SR9009, so it may be seen as an extremely safe compound. Since Stenabolic is not a hormonal drug, it does not aromatize into estrogen. Moreover, just like in the case of other SARMS, SR9009 is not liver toxic, but there is a need for liver supporting supplements when using it. N2Guard at 3-5 capsules per day will be sufficient liver and kidney support.
Adrafinil is a discontinued wakefulness-promoting agent (or eugeroic) that was formerly used in France to promote vigilance (alertness), attention, wakefulness, mood, and other parameters, particularly in the elderly.
It was also used off-label by individuals who wished to avoid fatigue, such as night workers or others who needed to stay awake and alert for long periods of time.
"Adrafinil is known to a larger nonscientific audience, where it is considered to be a nootropic agent."; Adrafinil is a prodrug; resulting in very similar pharmacological effects.
however, it takes time for the metabolite to accumulate to active levels in the bloodstream. Effects usually are apparent within 45–60 minutes when taken orally on an empty stomach.
1. Adrafinil can use for the treatment of Alzheimers dementia, cognition disorders, neurologic drugs, senile dementia, acetylcholine release enhancers.
2. Adrafinil can stay awake.
3. Adrafinil can treatment of Alzheimers.
4. Adrafinil can relieve excessive sleepiness and inattention in elderly patients.
|
|
10/15/2019 10:18:53 AM
|
|
China Weight Loss Raw Powder Belviq Lorcaserin HCl
|
China Weight Loss Raw Powder Belviq Lorcaserin HCl/Lorcaserin
Product Name: Lorcaserin Hcl weight loss powder
English name: Lorcaserin hydrochloride
English Synonyms: (1R) -8-Chloro-2,3,4,5-tetrahydro-1-methyl-1H-3-benzazepine hydrochloride; APD 356; APD-356; UNII-0QJF08GDPE; Lorcaserin HCl; (R) - 1H-3-Benzazepine, 8-Chloro-2,3,4,5-Tetrahydro-1-Methyl-, Hydrochloride
CAS: 846589-98-8
Formula: C11H14ClN · ClH
MW: 232.1525
Molecular Structure:
Assay:96.21%
Appearance:white powder
Boiling point : 288.125°C at 760 mmHg
Flash point : 128.054°C
Product usage : Medicine reducing weight and antidepressants
Description:
Belviq(Lorcaserin hydrochloride) is an FDA-approved prescription weight-loss medication that, when used with diet and exercise, can help some overweight? adults with a weight-related medical problem, or obese adults, lose weight and keep it off. It is not known if BELVIQ when taken with other prescription, over-the-counter, or herbal weight-loss products is safe and effective. It is not known if BELVIQ changes your risk of heart problems, stroke, or death due to heart problems or stroke.
Applications:
Belviq is a serotonin 2C receptor agonist. It hasbeen shown to decrease food consumption and promote satiety by selectivelyactivating serotonin 2C receptors in the brain.
Belviq is specifically indicated as an adjunct to a reduced-calorie diet andincreased physical activity for chronic weight management in clinically obeseadults (BMI of 30 kg/m2 or greater) and overweight adults (BMI of 27 kg/m2 orgreater) with at least one weight-related comorbid condition.
Belviq is supplied as a tablet designed for oral administration. The recommendeddose is one 10mg tablet twice daily. Use of Belviq should be discontinued if 5%weight loss is not achieved by week 12 of treatment.
|
|
10/15/2019 10:21:48 AM
|
|
Lorcaserin HCl for Weight-Loss
|
Lorcaserin HCl for Weight-Loss
Belviq(Lorcaserin hydrochloride) is an FDA-approved prescription weight-loss medication that, when used with diet and exercise, can help some overweight? adults with a weight-related medical problem, or obese adults, lose weight and keep it off. It is not known if BELVIQ when taken with other prescription, over-the-counter, or herbal weight-loss products is safe and effective. It is not known if BELVIQ changes your risk of heart problems, stroke, or death due to heart problems or stroke.Lorcaserin hcl
Applications:
Belviq is a serotonin 2C receptor agonist. It hasbeen shown to decrease food consumption and promote satiety by selectivelyactivating serotonin 2C receptors in the brain.
Belviq is specifically indicated as an adjunct to a reduced-calorie diet andincreased physical activity for chronic weight management in clinically obeseadults (BMI of 30 kg/m2 or greater) and overweight adults (BMI of 27 kg/m2 orgreater) with at least one weight-related comorbid condition.
Belviq is supplied as a tablet designed for oral administration. The recommendeddose is one 10mg tablet twice daily. Use of Belviq should be discontinued if 5%weight loss is not achieved by week 12 of treatment.
Lorcaserin Product Name: LORCASERIN
Lorcaserin Synonyms: LORCASERIN; (R)-8-Chloro-1-methyl-2, 3, 4, 5-tetrahydro-1H-3-benzazepine; Apd 356; Apd356; Apd-356; Ar-10a; Unii-637E494o0z; (1R)-8-Chloro-2, 3, 4, 5-tetrahydro-1-Methyl-1H-3-benzazepine
Lorcaserin CAS: 616202-92-7
Lorcaserin MF: C11H14ClN
Lorcaserin MW: 195.692
Lorcaserin EINECS:
Lorcaserin Product Categories: Amines; Aromatics; Chiral Reagents; Heterocycles; Intermediates & Fine Chemicals; Pharmaceuticals
Lorcaserin Mol File: 616202-92-7. mol
Lorcaserin Hydrochloride (Belviq) is an FDA-approved prescription weight-loss medication that, when used with diet and exercise, can help some overweight† adults with a weight-related medical problem, or obese adults, lose weight and keep it off. It is not known if BELVIQ when taken with other prescription, over-the-counter, or herbal weight-loss products is safe and effective. It is not known if BELVIQ changes your risk of heart problems, stroke, or death due to heart problems or stroke.
|
|
10/15/2019 10:25:11 AM
|
|
China Factory Supply AC-262536
|
China Factory Supply AC-262536
Product name:AC-262536
CAS: 870888-46-3
Molar Mass: 278.348 g/mol
Chemical Formula: C18H18N2O
Chemical Name: 4-(3-hydroxy-8-azabicyclo[3.2.1]octan-8-yl)naphthalene-1-carbonitrile
Synonyms: AC-262,536, AC-262536, CHEMBL468938, SCHEMBL4879629
Storage: 2-8°C.
Solubility: Ethanol.
Melting point: 158-162 °C.
Description:
AC-262536 Informations:
AC-262536 is a compound which acts as a selective androgen receptor modulator. Chemically it possesses endo-exo isomerism, with the endo form being the active form.
Activity of AC-262536:
AC-262536 is a drug developed by Acadia Pharmaceuticals which acts as a selective androgen receptor modulator. Chemically it possesses endo-exo isomerism, with the endo form being the active form. It acts as apartial agonist for the androgen receptor with a Ki of 5nM, and no significant affinity for any other receptors tested. In animal studies it produced a maximal effect of around 66% of the anabolic action, but only around 27% of its potency as an androgen.
|
|
10/23/2019 12:52:46 PM
|
|
Raloxifene Hydrochloride Tablets
|
Raloxifene Hydrochloride Tablets
Raloxifene Hydrochloride Tablets, USP is indicated for the reduction in risk of invasive breast cancer in postmenopausal women at high risk of invasive breast cancer [see Clinical Studies (14.4)].
The effect in the reduction in the incidence of breast cancer was shown in a study of postmenopausal women at high risk for breast cancer with a 5-year planned duration with a median follow-up of 4.3 years [see Clinical Studies (14.4)]. Twenty-seven percent of the participants received drug for 5 years. The long-term effects and the recommended length of treatment are not known.
High risk of breast cancer is defined as at least one breast biopsy showing lobular carcinoma in situ (LCIS) or atypical hyperplasia, one or more first-degree relatives with breast cancer, or a 5-year predicted risk of breast cancer ≥1.66% (based on the modified Gail model). Among the factors included in the modified Gail model are the following: current age, number of first-degree relatives with breast cancer, number of breast biopsies, age at menarche, nulliparity or age of first live birth. Currently, no single clinical finding or test result can quantify risk of breast cancer with certainty.
After an assessment of the risk of developing breast cancer, the decision regarding therapy with Raloxifene Hydrochloride Tablets, USP should be based upon an individual assessment of the benefits and risks.
Raloxifene Hydrochloride Tablets, USP does not eliminate the risk of breast cancer. Patients should have breast exams and mammograms before starting Raloxifene Hydrochloride Tablets, USP and should continue regular breast exams and mammograms in keeping with good medical practice after beginning treatment with Raloxifene Hydrochloride Tablets, USP.
For either osteoporosis treatment or prevention, supplemental calcium and/or vitamin D should be added to the diet if daily intake is inadequate. Postmenopausal women require an average of 1500 mg/day of elemental calcium. Total daily intake of calcium above 1500 mg has not demonstrated additional bone benefits while daily intake above 2000 mg has been associated with increased risk of adverse effects, including hypercalcemia and kidney stones. The recommended intake of vitamin D is 400 to 800 IU daily. Patients at increased risk for vitamin D insufficiency (e.g., over the age of 70 years, nursing home bound, or chronically ill) may need additional vitamin D supplements. Patients with gastrointestinal malabsorption syndromes may require higher doses of vitamin D supplementation and measurement of 25-hydroxyvitamin D should be considered.
In clinical trials, raloxifene-treated women had an increased risk of venous thromboembolism (deep vein thrombosis and pulmonary embolism). Other venous thromboembolic events also could occur. A less serious event, superficial thrombophlebitis, also has been reported more frequently with raloxifene than with placebo. The greatest risk for deep vein thrombosis and pulmonary embolism occurs during the first 4 months of treatment, and the magnitude of risk appears to be similar to the reported risk associated with use of hormone therapy. Because immobilization increases the risk for venous thromboembolic events independent of therapy, raloxifene should be discontinued at least 72 hours prior to and during prolonged immobilization (e.g., post-surgical recovery, prolonged bed rest), and raloxifene therapy should be resumed only after the patient is fully ambulatory. In addition, women taking raloxifene should be advised to move about periodically during prolonged travel. The risk-benefit balance should be considered in women at risk of thromboembolic disease for other reasons, such as congestive heart failure, superficial thrombophlebitis, and active malignancy [see Contraindications (4.1) and Adverse Reactions (6.1)].
|
|
10/23/2019 12:55:57 PM
|
|
Tulobuterol Hydrochloride Market Insights 2019
|
Tulobuterol Hydrochloride Market Insights 2019
Tulobuterol hydrochloride powder Market, Global Tulobuterol Hydrochloride Market, Chinese Tulobuterol Hydrochloride Market, Tulobuterol Hydrochloride Price, Tulobuterol Hydrochloride Market Size, Tulobuterol Hydrochloride Market Share, Tulobuterol Hydrochloride Market Trend, Tulobuterol Hydrochloride Market Analysis, Tulobuterol Hydrochloride Market Forecast
Tulobuterol Hydrochloride Market Insights 2019, Global and Chinese Scenario is a professional and in-depth study on the current state of the global Tulobuterol Hydrochloride industry with a focus on the Chinese market. The report provides key statistics on the market status of the Tulobuterol Hydrochloride manufacturers and is a valuable source of guidance and direction for companies and individuals interested in the industry.Overall, the report provides an in-depth insight of 2014-2024 global and Chinese Tulobuterol Hydrochloride market covering all important parameters.
The key points of the report:
1.The report provides a basic overview of the industry including its definition, applications and manufacturing technology.
2.The report explores the international and Chinese major industry players in detail. In this part, the report presents the company profile, product specifications, capacity, production value, and 2014-2019 market shares for each company.
3.Through the statistical analysis, the report depicts the global and Chinese total market of Tulobuterol Hydrochloride industry including capacity, production, production value, cost/profit, supply/demand and Chinese import/export.
4.The total market is further divided by company, by country, and by application/type for the competitive landscape analysis.
5.The report then estimates 2019-2024 market development trends of Tulobuterol Hydrochloride industry. Analysis of upstream raw materials, downstream demand, and current market dynamics is also carried out.
6.The report makes some important proposals for a new project of Tulobuterol Hydrochloride Industry before evaluating its feasibility.
There are 3 key segments covered in this report: competitor segment, product type segment, end use/application segment.For competitor segment, the report includes global key players of Tulobuterol Hydrochloride as well as some small players.
|
|
10/23/2019 12:59:40 PM
|
|
Global Tulobuterol Hydrochloride Market Top Vendor
|
Global Tulobuterol Hydrochloride Market Top Vendors
The global market size of Tulobuterol hydrochloride is $XX million in 2018 with XX CAGR from 2014 to 2018, and it is expected to reach $XX million by the end of 2024 with a CAGR of XX% from 2019 to 2024.
Global Tulobuterol Hydrochloride Market Report 2019 – Market Size, Share, Price, Trend and Forecast is a professional and in-depth study on the current state of the global Tulobuterol Hydrochloride industry. The key insights of the report:
1.The report provides key statistics on the market status of the Tulobuterol Hydrochloride manufacturers and is a valuable source of guidance and direction for companies and individuals interested in the industry.
2.The report provides a basic overview of the industry including its definition, applications and manufacturing technology.
3.The report presents the company profile, product specifications, capacity, production value, and 2013-2018 market shares for key vendors.
4.The total market is further divided by company, by country, and by application/type for the competitive landscape analysis.
5.The report estimates 2019-2024 market development trends of Tulobuterol Hydrochloride industry.
6.Analysis of upstream raw materials, downstream demand, and current market dynamics is also carried out
7.The report makes some important proposals for a new project of Tulobuterol Hydrochloride Industry before evaluating its feasibility.
There are 4 key segments covered in this report: competitor segment, product type segment, end use/application segment and geography segment.
For competitor segment, the report includes global key players of Tulobuterol Hydrochloride as well as some small players.
|
|
10/23/2019 1:01:50 PM
|
|
Cimaterol powder General Description
|
Cimaterol powder General Description
Cimaterol powder is a chemically stable nonselective agonist β1-, β2-, and β3-adrenoceptors. Cimaterol is used in sport as a stimulant and a fat burner that assists bodybuilders and strength athletes to get rid of body fats. Aside from shedding off fats, another benefit for using cimaterol for athletes is a boost in strength as well as an increase in muscle size or lean body mass. The increase in muscle size has been seen in previous animal studies when cimaterol is used. However, the reason behind the muscle gain is not identified yet, but the body has a very different response compared from taking in anabolic steroids. Experts in the field are saying that the increased nitrogen retention, that is known to cause by cimaterol, maybe the reason behind the muscle gain. Another great thing about Cimaterol is that, it can improve blood flow.
Beta-adrenergic agonists, or β-agonists, are non-hormonal growth promotants that help animals put on muscle instead of fat. The more scientifically accepted name for agents of this class is a repartitioning agent, not a growth promotor. Ractopamine (brand names include Optaflexx and Paylean) and zilpaterol (brand name Zilmax) received FDA approval in 1999 and 2003, respectively. They are also approved in Mexico, South Africa, and Canada. 160 countries restrict the importation of beef which has been raised with β-agonists. Temple Grandin was one of the first to describe the potential problems with the supplement. Cattle may arrive at the plant with a stiff gait, acting like they have both stiff muscles and sore feet. The problem could be muscle fatigue. Zilpateral enhances the growth of “fast-twitch” fibers, a type of muscle fiber that fatigues more easily. On August 16, 2013 Merck and Co., the makers of Zilmax, suspended the sale of the product in the US and Canada. But problems may exist with all β-agonists supplementation, and not just for animals.
The effect of beta-agonists on plasma hormone levels is an important consideration when assessing the possible modes of action of these drugs in promoting growth. Thus, a study was carried out in which 50 young male rats (10 per treatment and 20 controls) were fed clenbuterol at 10 ppm, BRL35135 at 15 ppm, or L-640,033 at 15 ppm for 2 weeks (L. A. Muir, unpublished data). At necropsy, gastrocnemius muscle and epididymal fat pad weights were measured to assess the effects of the beta-agonists on skeletal muscle protein and carcass lipids. In addition, blood samples were obtained and assayed for plasma growth hormone, insulin, somatomedin-C (SM-C), and glucose.
07 Cimaterol (54239-37-1) Application
Interest in methods to improve the efficiency of animal production has focused on betaadregenic agonists such as cimaterol in recent years. Cimaterol has been recognised as a repartitioning agent that improves carcass composition by increasing muscle deposition and reducing fat. It also has the ability to accelerate livestock growth. In human however, they are generally used as anti-asthmatic agent. Therefore, excess cimaterol residues in livestock products may pose a genuine risk for human health. This has led to the prohibition of cimaterol usage in every stage of food production. To know whether food matrices contain cimaterol residue, one must need to test it.
|
|
10/23/2019 1:04:23 PM
|
|
Alupent (Orciprenaline Sulfate)
|
Alupent (Orciprenaline Sulfate)
Orciprenaline powder is a bronchodilating agent. The bronchospasm associated with various pulmonary diseases – chronic bronchitis, pulmonary emphysema, bronchial asthma, silicosis, tuberculosis, sarcoidosis and carcinoma of the lung, has been successfully reversed by therapy with orciprenaline.
Orciprenaline has the following major characteristics: The action of orciprenaline is one of beta stimulation. Receptor sites in the bronchi and bronchioles are more sensitive to the drug than those in the heart and blood vessels, so that the ratio of bronchodilating to cardiovascular effects is favorable. Consequently, it is usually possible clinically to produce good bronchodilation at dosage levels which are unlikely to cause cardiovascular side effects.
The efficacy of the bronchodilator after both oral and inhalation administration has been demonstrated by pulmonary function studies (spirometry, and by measurements of airways resistance by body plethysmography).Rapid onset of action follows administration of orciprenaline inhalants, and the effect is usually noted immediately. Following oral administration, the effect is usually noted within 30 minutes.The peak effect of bronchodilator activity following orciprenaline generally occurs within 60 to 90 minutes, and this activity lasts for 3 to 6 hours.Orciprenaline taken orally potentiates the action of a bronchodilator inhalant administered 90 minutes later, whereas no additive effect occurs when the drugs are given in reverse order.
Patients have not developed tolerance to the drug during prolonged therapy.No toxic effects on the liver, kidneys or hematologic system have been reported in the long-term use of orciprenaline in man.Indications And Clinical Uses: Orciprenaline has been found useful in the following conditions: bronchial asthma, chronic bronchitis, pulmonary emphysema.Orciprenaline is also useful in sarcoidosis, silicosis, carcinoma of the lung and tuberculosis when bronchospasm contributes to the disability.
Patients with chronic airways obstructive disease require long-term therapy with bronchodilators as an essential part of overall management aimed at lowering airways resistance and facilitating bronchial drainage. Orciprenaline has been shown to fulfill the basic requirements of such continued therapy in that it is effective both orally and as an inhalant, has a rapid and prolonged action, and has a low incidence of side effects.
Inhalation Aerosol: The efficacy of orciprenaline administered as an aerosol has been demonstrated by increased flow rates (FEV1, MMFR, MEFR, MBC) decreased airways resistance (body plethysmography), and decreased functional residual capacity (body plethysmography).
In one study the effect of 4.5 mg of orciprenaline has been compared with the effect of 0.45 mg of isoproterenol each drug being given as an aerosol over a period of 8 minutes. Although the improvement in pulmonary function was consistently better with orciprenaline, 1 hour, 3 hours, and 6 hours following inhalation, changes in pulse rate and blood pressure were less pronounced with orciprenaline. This indicated a more favorable ratio of bronchodilating to cardiovascular effects for orciprenaline.
In another study, orciprenaline 2% solution, racemic epinephrine 2.25% and isoproterenol 1% were each administered as aerosols on separate days. The aerosols were administered by hand nebulizer for 30 minutes or until cardiovascular side effects appeared.
|
|
10/23/2019 1:08:04 PM
|
|
Orciprenaline powder General Description
|
Orciprenaline powder General Description
Orciprenaline powder is a bronchodilator used in the treatment of asthma. Orciprenaline is a moderately selective β2 adrenergic receptor agonist that stimulates receptors of the smooth muscle in the lungs, uterus, and vasculature supplying skeletal muscle, with minimal or no effect on α adrenergic receptors. The pharmacologic effects of β adrenergic agonist drugs, such as orciprenaline, are at least in part attributable to stimulation through β adrenergic receptors of intracellular adenylyl cyclase, the enzyme which catalyzes the conversion of ATP to cAMP. Increased cAMP levels are associated with relaxation of bronchial smooth muscle and inhibition of release of mediators of immediate hypersensitivity from many cells, especially from mast cells.
Orciprenaline is only found in individuals that have used or taken this drug. It is a beta-adrenergic agonist used in the treatment of asthma and bronchospasms. Orciprenaline is a moderately selective beta(2)-adrenergic agonist that stimulates receptors of the smooth muscle in the lungs, uterus, and vasculature supplying skeletal muscle, with minimal or no effect on alpha-adrenergic receptors. Intracellularly, the actions of orciprenaline are mediated by cAMP, the production of which is augmented by beta stimulation. The drug is believed to work by activating adenylate cyclase, the enzyme responsible for producing the cellular mediator cAMP.
Orciprenaline stimulates the β2-adrenergic receptor expressed in the lungs, uterus, and vasculature supplying skeletal muscles by acting as a moderately selective agonist. It exerts minimal or no effect on alpha-adrenergic receptors. Intracellularly, the actions of orciprenaline are mediated by cAMP, the production of which is augmented by beta stimulation. The drug is believed to work by activating adenylate cyclase, the enzyme responsible for producing the cellular mediator cAMP.
Orciprenaline (also known as metaproterenol), a synthetic amine, is structurally and pharmacologically similar to isoproterenol. Orciprenaline is used exclusively as a bronchodilator. The pharmacological effects of beta adrenergic agonist drugs, such as orciprenaline, are at least in part attributable to stimulation through beta adrenergic receptors of intracellular adenyl cyclase, the enzyme which catalyzes the conversion of adenosine triphosphate (ATP) to cyclic- 3′,5′- adenosine monophosphate (c-AMP). Increased cAMP levels lead to relaxation of bronchial smooth muscles and inhibition of the release of inalammatory mediators from mast cells that are involved in promoting immediate hypersensitivity.
|
|
1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20
|