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9/20/2019 12:30:57 PM
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It appears that Kanye West wants your closet to be
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It appears that Kanye West wants your closet to be full of Yeezys.
Sneaker leak social media account Yeezy Season posted via Instagram info on three potential Adidas Yeezy Powerphase releases slated for this month. T“Clear Brown” and “Quiet Grey” iterations of the simple and clean silhouette.
The release date for the shoes, according to Yeezy Season, is scheduled for Sept. 18. Although no pricing info was shared, past Powerphase colorways retailed for $120.The rapper-turned-designer has been on a tear with sneaker releases lately. Aside from teasing the Foam Runner and the Boost 350 V3, there have been several drops or shoes slated for release before month’s end, including the Boost 700 “Magnet,” the 700 V2 “Inertia,” new colorways of the Desert Boot, the “Hospital Blue” Boost 700 V2, the “Cloud White” and “Citrin” 350 V2, and an all-black Yeezy basketball sneaker.get Cheap Yeezy 350 Static,more order with big discount
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Kanye Sports Yeezy Boost 700s to Surprise Manager With a Lamborghini
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9/20/2019 12:35:58 PM
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1. What is Testosterone decanoate? How does it wor
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1. What is Testosterone decanoate? How does it work?
Testosterone decanoate powder supplier (5721-91-5) is among the most used steroids on the market by athletes and bodybuilders. The drug is mostly sold under different brands names in various markets, but Neotest 250 has stood out as the most known testosterone decanoate brand. This drug was initially manufactured as a veterinary drug before it was realized it could help bodybuilders to achieve their career goals. Neotest 250 is produced and combined with a single large ester derived from the testosterone decanoate. Actually, this single ester compound is among the largest esters on the market today, and you can only get it as part of a combined mix. The Neotest single ester supplement is used as part of a majority of various testosterone blends such as Omnadren and Sustanon 250 to mention a few. Today, it can be hard for you to find Neotest 250 on the market.
How does it work?
As mentioned earlier, decanoate is a long ester that is usually attached to various anabolic steroids to enable them to deliver quality results and stay in your body system for a more extended period. Testosterone decanoate (5721-91-5) is an injectable anabolic steroid that means you will have to inject your dosage within the stipulated intervals by your doctor for the entire cycle. Esters don’t interfere with the abilities and functions of testosterone, but it only enables the compound to act for a more extended period. Long esters translate to longer testosterone active half-life in your body while the short esters mean that the drug will have a short active life. The speed at which testosterone decanoate is released in your body ensures a consistent and steady supply for the testosterone hormone and becomes active after just one injection.
Testosterone decanoate(5721-91-5) has an androgenic score of 100/100. These ratings or scores are used in measuring the strength of every anabolic steroid on the market. This steroid has a long and moderate active half-life when injected into your body system than the testosterone cypionate which is said to offer similar results. Therefore, these properties make Neotest 250 the best solution to the treatment of testosterone deficiency. Another best part of the testosterone decanoate is that once injected; your body cannot differentiate it from the natural one meaning you will enjoy excellent results by the end of your cycle.
The drug operates just like the natural testosterone hormone which enhances men characteristics such as the growth of beards, deepening of voice and building of muscles among others. Testosterone hormone is also responsible for the sexual drive more so on men and is recommended for patients who have erectile dysfunction or impotence. However, the natural testosterone hormone might not be enough to enable athletes or bodybuilders to gain the desired body strength and muscles. That’s the reason why many athletes prefer taking steroids to improve the testosterone hormone production in the body. Accompanying your testosterone decanoate dosage with proper diet and workout could make it easy for you to attain your goals within the shortest time possible.
The most common testosterone decanoate(5721-91-5) blends on the market are all developed to solve the low testosterone hormone problem. The original Omnadren had Caproate ester instead of the decanoate ester, but the current blend contains testosterone decanoate ester after the realization that it’s more effective and is mixed with a 1ml ampule. That brings the Neotest compound total dosage to 250mg, and the breakdown is as follows;
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9/20/2019 12:38:29 PM
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Testosterone Decanoate CAS 5721-91-5
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Testosterone Decanoate CAS 5721-91-5
Testosterone decanoate bodybuilding, a.k.a. Neotest 250, is probably best known as one of the ingredients in Sustanon. Neotest 250 is testosterone with the decanoate ester, a slow-acting long ester, similar to testosterone enanthate.
Testosterone decanoate commonly used in intramuscular injection solution, the oil absorption is slow, function is strong and durable, can maintain time for just a few days. More specifically, Neotests decanoate ester releases for approximately three weeks after the injection, making it similar to but slightly slower than both the cypionate and enanthate esters. At present, the decanoate version of testosterone can only be found within sustanon 250.
Testosterone Decanoate is the most commonly associated brand name to the Testosterone Decanoate product. This is an injectable testosterone hormone attached to the large / long Decanoate ester. The ester itself does not affect the compounds functions and traits; no ester has this ability. However, the attached Decanoate ester does affect the testosterone hormone's release time. This will be a very slow acting testosterone, and it will provide a slow, steady release of the hormone after a single injection.
Testosterone Decanoate As with all forms of testosterone, this product will cause weight and strength gain, fat loss, a libido increase, an increase in IGF-1 levels, Red Blood Cell count, and of course increased recovery from training.
Again, as with all forms of testosterone it is subject to aromatization as well as 5alpha-reduction, which are the pathways through which testosterone is converted to estrogen and dihydrotestosterone respectively. Excess build up of estrogen can be responsible for gynocomastia (development of female breast tissue in males) as well as bloating and water retention. Dihydrotestosterone can cause both acne as well as hair loss.
As with all forms of exogenous hormones, using this product will shut down your body's natural production of testosterone. In addition, cholesterol, immune function, and several other health markers may be adversely affected.
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9/20/2019 12:41:16 PM
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Testosterone decanoate Uses
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Testosterone decanoate Uses
Initially, when the drug was manufactured in Mexico, it was used for veterinary purposes, but today the compound is used by human beings. Testosterone has been essential in both the medical and sporting world. Bodybuilders have been using the compound for many years, and it has proven to be excellent in providing quality muscles. Currently, despite the drug only being available on the underground labs, still attacks massive demand from the athletes as well as the doctors to treat patients with various low testosterone problems.Testosterone decanoate dosage
Men mainly use testosterone decanoate under prescription as a solution to low testosterone hormone production. Actually, the compound is used in the testosterone replacement therapy to help male patients recover and get back to a quality life. Lack of testosterone hormone in the body can lead to various problems such as low libido, impotence or even erectile dysfunction as well as improve the levels of body fats being deposited on the chest and hips. There are many health problems more so in men that result from the low levels of testosterone hormone. When you are suffering from such issues, then your doctor will always recommend the use of testosterone decanoate.
On the other hand, testosterone decanoate is also used in the treatment of diseases that result in a reduction of muscle mass such as HIV/AIDS. Patients will need to build muscles as well as enhance their body strength. For many years, doctors have successfully used this anabolic steroid to help patients gain and maintain their muscles while under treatment for the primary disease. However, if you have this problem don’t just buy the drug even if you can easily access it before approval or prescription from your doctor. It also reported that testosterone decanoate could also help users improve their focus as well as solve the insomnia problem. As much as this anabolic steroid enhances the production of red blood cells, still it’s not clear whether the drug can help in the treatment of anemia. Some researchers are currently carrying out studies to determine if the compound can help anemic individuals.
In the sporting world, testosterone decanoate (5721-91-5) has proved to be effective in helping athletes and bodybuilders achieve their career goals. Lack of enough body strength is the main reason why many athletes are unable to compete effectively or even win their competitions. However, testosterone decanoate has proved to be a blessing to many elite athletes. For bodybuilders who wish to gain quality muscles and strength to work out properly, this drug is what they need. When appropriately stacked or accompanied by proper diet and training, it delivers quality muscle mass. The drug can improve nitrogen retention in your muscles, which is an excellent ingredient for quality muscle development.
In addition, testosterone decanoate also enhances the production of red blood cells which in turn ensures there is a steady supply of nutrients to the muscles. Normally, when you work out for long especially in the bulking cycles, your muscles might tear or stretch resulting in some pains. However, the steady supply of nutrients ensures that the body tissues heal naturally and within the shortest time possible. This also helps in muscle mass development and improvement of the overall body strength. If your joints or muscle pains have prolonged than usual inform your doctor in good time. Make sure that your nutritionist and trainer are also aware that you are using testosterone decanoate or any other steroid.
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9/20/2019 12:44:13 PM
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Testosterone decanoate dosage
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Testosterone decanoate dosage
Currently, it’s tough to find testosterone Testosterone decanoate benefits as a sole supplement since there is on known manufacturer on the market. The compound is mostly found as a blend or mix of another testosterone compound. It will, therefore, be hard for your doctor to prescribe testosterone decanoate alone unless you use another compound that contains the supplement as part of the ingredients. Looking for the Neotest 250 on the underground labs or black market you might have a hard time since many labs rarely have the drug. Thus, it’s advisable to look for testosterone decanoate as a blend with Sustanon or Omnadren. On the other hand, you can easily get the testosterone decanoate online from reliable manufacturers or vendors. Do your research to understand how the vendor or manufacturer operates to avoid disappointments.
All in all, after getting the drug make sure the dosage is around 500mg per week more so if you wish to enhance your overall performance. The dosage will also be enough for the patients experiencing low testosterone symptoms. If your body is used to Neotest 250, your doctor can advise you to take higher dosages ranging from 750mg to 100mg per week. Majority of the Neotest 250 male users take a minimum of 500mg per week while others take higher than that; it all depends on your body tolerance. However, it’s advisable that you consult with your doctor to help you set the right dosage for you. Sometimes, the drug users can take low dosages and experience severe side effects which force the doctor to lower the dosage further.
It is also possible for some users to take higher dosages and still fail to experience the desired results. Human bodies are different, and that’s why it’s essential to go for a medical checkup before and after taking testosterone decanoate. There are also other users who experience severe side effects when they take higher Neotest 250 dosages. Stick to the stipulated dosage by your doctor and also ensure that you take the injections correctly. If you are not sure about injecting yourself, inform your doctor to train you how to administer the drug. Unprofessional injection administration could lead to health complications. Neotest 250 could also be an excellent choice for athletes suffering from testosterone suppression which results from the use of other anabolic steroids. Here a dosage of 250mgs per 7/10 days will be enough to get the hormones back on the right track.
The testosterone decanoate injections could be painful, but that should not be a problem since you understand what you wish to achieve by the end of the cycle. You can rotate the injection areas to avoid chronic pains, but your doctor can also provide you with some medications to help you control the injection area pains. However, you will only need to inject yourself once in a week since it’s a long ester drug. That will give you enough time to recover before taking the next injection. In case the pains persist, inform your doctor immediately. To be safe also, make sure you stick to the instructions given by your medic and ensure you go for regular medical examination while pursuing your cycle.
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9/20/2019 12:47:39 PM
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High Purity Seroid Powder Oxymetholone (Anadrol)
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High Purity Seroid Powder Oxymetholone (Anadrol)
Anadrol powder supplier, commonly known as Anadrol due to the first manufactured name of the steroid is derived from Dihydrotestosterone (DHT) and is a 17-Alpha-Alkylated steroid (17-aa.) The 17-aa alteration simply means the steroid has been chemically altered at the 17th carbon position to allow it to survive ingestion by surviving the first pass through the liver; without the 17-aa alteration the steroid would be destroyed before it ever entered the blood stream. The good news is by this alteration we are able to absorb a usable and powerful anabolic steroid; the bad news is this is toxic to the liver. As most oral steroids are 17-aa the toxic effect can be quite high but as it pertains to Anadrol this effect is more pronounced making it one of the most liver toxic steroids on the market.
Once oxymetholone enters the body, which is allowed by its 17-aa form it will become active very quickly and the effects will be dramatically fast. As we understand anabolic androgenic steroids the half-life associated with them largely affects the initial potency; Oxymetholone has a very short half-life of approximately 8.5 hours making the steroids activity almost instant but with a very short active duration. For this reason many athletes will split their Oxymetholone dose into two doses per day in order to keep a peak amount of the steroid active in their system around the clock during periods of use. However, one dose per day will be enough to keep an active amount of the steroid functioning in the body, although not at peak levels.
Applications :
Anadrol is the strongset effective oral steroid and has an extremely androgenic which hand in hand with an extremely intense anabolic component, by taking the Anadrol the athletes experiences an enormous"pump effect" during the workout in the exercised muscles. It self as an anabolic hormone drugs, can promote protein synthesis and inhibiting protein dysplasia, and can lower blood cholesterol, reduce calcium phosphorus excretion and reduce bone marrow suppression, promoting development, promote tissue freshmen and granulation. Caused by long-term use of adrenal cortical hormone have prevention and protection against the adrenal cortex hypofunction.
Second only to Dianabol (methandrostenolone) as a bodybuilding anabolic steroid. Additionally, it has had considerable medical importance particularly for treatment of anemia, and more recently to help maintain lean body mass in HIV-compromised patients. Alienation can promote protein synthesis and inhibiting protein, and can lower blood cholesterol, reduce calcium phosphorus excretion and reduce bone marrow suppression, promote development and so on. Oxymetholones (Anadrol, Anadrol 50, Androyd) is one of the most popular anabolic steroids of all time in both performance and medical circles.
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9/20/2019 12:50:50 PM
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WHAT IS ANADROL(OXYMETHOLONE)？
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WHAT IS ANADROL(OXYMETHOLONE)？
Anadrol bodybuilding (Oxymetholone) is an oral anabolic steroid derived from dihydrotestosterone. More specifically, it is simply a methyldihydrotestosterone formed by the addition of a 2-hydroxymethylene group. This produces a similar steroid, which is significantly different in activity compared to methenolone, but it is difficult to compare between the two. For beginners, Anadrol is a very effective anabolic hormone. Since these molecules are not very stable in the high enzyme (3-alpha hydroxysteroid dehydrogenase) environment of muscle tissue, both dihydrotestosterone and methenolone are very weak. Oxygen free radicals remain highly active here, and as reported in standard animal assays, they have higher anabolic activity than testosterone or methyltestosterone. Such assays indicate that Anadrol is also very low in androgenicity. Many people think that Anadrol is the most powerful steroid on the market. A newcomer using steroids may get 20 to 30 pounds of weight, and usually achieve this effect within 6 weeks of use. This steroid will cause the body to store a large amount of water, so a large part of this increased body weight will be water. This usually has little effect on the user, and they feel great and strong when taking Anadrol. Although the smooth appearance obtained by water storage is usually not attractive, it can greatly increase the size and strength. The muscles are fuller, contractile, and provide a degree of protection from additional water and connective tissue. This will gain more flexibility and will hopefully reduce the chance of serious weight loss. However, it should be noted that very fast mass gains can also put too much stress on connective tissue. Tears of the pectoral and biceps tissues are often associated with heavy weight lifting.
History: Anadrol (Oxymetholone) first appeared in 1959. The drug was prescribed in the United States in the early 1960s and sold under the brand names Anadrol-50 (Syntex) and Androyd (Parke Davis & Co.) Syntex became an agent and held patents until many years later. Expiration. The drug was originally approved for use in conditions requiring anabolic effects. Indications include ageing weakness, chronic underweight condition, pre-operative and postoperative maintenance of lean body mass, infection recovery, gastrointestinal disease, Osteoporosis and general catabolic conditions. The recommended dose for this use is usually 2.5 mg once daily three times a day. The drug is initially given as a 2.5 mg, 5 mg or 10 mg tablet. Although the drug has many potentials Therapeutic use and strong anabolic activity, but the FDA quickly narrowed the use of Anadrol. By the mid-1970s, the drug was approved by the FDA for treatment only with red blood cell (RBC) deficiency. Anemia. It is true that stimulating erythropoiesis is characteristic of almost all anabolic steroids, and they are used as a group to increase red blood cell concentration. However, in this regard, Anadrol seems to When reliable; can increase erythropoietin levels up to 5-fold. This has led to the adoption of this relatively new medical use, as well as the use of newer Anadrol-50 products to prepare higher (50mg) doses. This has a greater impact on RBC counts. However, the Park Davis project will not be raised to higher doses and has stopped. In recent years, there have been some new treatments for anemia, especially It uses Epogen (recombinant erythropoietin) and related erythropoietin peptides. These drugs directly mimic the body's natural erythropoietin, thus providing a more concentrated treatment and producing fewer males.
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9/20/2019 12:53:10 PM
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Everything You Need To Know About Anadrol (Oxymeth
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Everything You Need To Know About Anadrol (Oxymetholone) for Bodybuilding
The use of anabolic steroids continues to make sports headlines as bodybuilders and athletes use them to stay in tip top shape. Most users take these performance-enhancing and strength-boosting steroids in the hopes that they will boost their ability to lift heavier weights, hit farther, run faster, or jump higher. If you are out looking for an anabolic steroid that will help you achieve all that, you should consider buying Anadrol(Oxymetholone).Anadrol dosage
Anadrol (434-07-1)is an oral steroid that belongs to the group of medications known as anabolic steroids and it is actually the brand name for Oxymetholone. It is derived from Dihydrotestoterone, and is considered one of the most effective anabolic androgenic steroids (AAS) on the market today. This steroid is also widely marketed as Anadrol 50, which generally means that it’s dosed at 50 mg per pill/tablet.
Oxymetholone (434-07-1) is the generic name of Anadrol and its chemical name is 17ß-hydroxy-2-(hydroxymethylene)-17-methyl-5a-androstan-3-one. The following are its properties:
CAS ID – 434-07-1
Molecular formula – C21H32O3
Molar Mass – 332.48 g/mol
Melting point – 178° to 180°C
Active ingredient – Oxymetholone
Inactive ingredients – magnesium stearate, lactose, starch, povidone
Similar to other anabolic androgenic steroids, Oxymetholone is an agonist of the androgen receptor. The drug is not a substrate for 5a-reductase and it is a poor substrate for 3a-hydroxysteroid dehydrogenase. For this reason, Oxymetholone exhibits a high ratio of anabolic to androgenic activity, which is 320:45. This means that this synthetic steroid has strong anabolic effects and weak androgenic effects.
The history of Oxymetholone goes way back to the early 1960s, when a 30-days study involving aids patients who were suffering from muscle wastage was carried out. At the end of the study period, the patients had gained an average of 8 kilograms.
People were first brought to the attention of Oxymetholone in 1956 paper. It was until 1961 when Syntex and Imperial Chemical Industries introduced the drug to the market for medical use in the United Kingdom under the brand name Anapolon. It wasn’t long before bodybuilders got wind of this drug owing to its ability to help users gain muscle.
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9/20/2019 12:54:41 PM
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Exemestane (Aromasin) Cas 107868-30-4 Anti-Estroge
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Exemestane (Aromasin) Cas 107868-30-4 Anti-Estrogen Raw Hormone Powder
Exemestane dosage is the second-generation aromatase inhibitor, for the treatment of metastatic breast cancer and as adjuvant therapy for early breast cancer.
Exemestane is a drug used to treat breast cancer. exeme stane is a member of the class of drugs known as aromatase inhibitors. exeme stane is indicated for the treatment of advanced breast cancer in postmenopausal women.
Basic details:
Product Name: Exemestane
CasNo: 107868-30-4
Molecular Formula: C20H24O2
Appearance: white crystalline powder
Application: Treat breast cancer drugs
DeliveryTime: 2~3 days after confirmation
PackAge: 1kg/foil bag;25kgs/drum
Port: Shanghai,Shenzhen,Hongkong
ProductionCapacity: 250 Kilogram/Month
Purity: 99.9%
Storage: preserve in a lell-closed container an...
Transportation: Express via HKEMS,Hongkong Post,FedEx,...
LimitNum: 10 Gram
Related Substances: ≤1%
Residue on Ignition: ≤0.2%
Heavy Metal: 10ppm max
Valid Period: 2 years
Melting point:: 191 ~ 195℃
absorption coefficient: 485 ~525
Sulfate: ≤0.01%
Toluene: ≤0.089%
Loss on drying: ≤0.5%
standard: Enterprise standard
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9/20/2019 12:57:20 PM
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Exemestane/AROMASIN-25
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Exemestane/AROMASIN-25
Aromasin (Exemestane uses) works as a steroidal aromatase inhibitor, functioning to reduce estrogen production by blocking the enzyme responsible. It was developed for postmenopausal women battling cancer and in particular need of aggressive therapy, where first-line medications have not worked successfully. On the average, Aromasin (exemestane) has an 85% rate for estrogen suppression, which makes it effective for treating cancer since certain cancers grow due to the body’s estrogen supply. Cut the estrogen and you help slow down the cancer. As for steroids use, Aromasin is a good option because male bodybuilders don’t have to worry about aromatization, the conversion of estrogen in the body, which is then responsible for side effects like acne, water retention, and gynecomastia. It is also not too harsh on blood lipids which make it great for long cycles. Since it also raises testosterone levels, it also makes fAromasinor a great component of a Post-Cycle-Therapy.
Directions
Your doctor will discuss with you how long you will take AROMASIN (exemestane). The recommended dose is one 25 mg tablet, once daily, by mouth. The tablet should be taken with food (preferably after a meal). Try to take your tablet at the same time each day. If you forget to take a dose of AROMASIN (exemestane), don’t worry, take the missed dose as soon as you remember. However, if it is almost time for the next dose, skip the missed dose and go back to your regular dosage schedule. Do not double dose. If you need to go into hospital while taking AROMASIN (exemestane), let the doctor know about your medication.
Possible side effects
AROMASIN (exemestane) like all other medicines, may cause unwanted effects in some people. Many women can take AROMASIN (exemestane) without any problems, but some women may have mild to moderate side effects. If you have any of the following side effects or other effects that you think may be related to your treatment, tell your doctor or pharmacist as soon as possible. The most frequently reported reactions are hot flashes, nausea, fatigue, dizziness and excessive sweating. Headache, sleeplessness, skin rash, increase of appetite, abdominal pain, depression, constipation and indigestion have also been reported. If you feel drowsy, dizzy or weak while taking AROMASIN (exemestane), do not drive or operate machinery.
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9/20/2019 12:59:39 PM
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98% Purity Exemestane Aromasin Powder
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98% Purity Exemestane Aromasin Powder
Exemestane powder supplier is a steroidal inhibitor of aromatase which effectively blocks estrogen synthesis in postmenopausal women and is used as therapy of estrogen receptor positive breast cancer, usually after resection and after failure of tamoxifen. Exemestane has been associated with a low rate of serum enzyme elevations during therapy and rare instances of clinically apparent liver injury.
Exemestane is a synthetic androgen analogue. Exemestane binds irreversibly to and inhibits the enzyme aromatase, thereby blocking the conversion of cholesterol to pregnenolone and the peripheral aromatization of androgenic precursors into estrogens.
Exemestane Aromasin Usage
This medication is used to treat certain types of breast cancer (such as hormone-receptor-positive breast cancer) in women after menopause. Exemestane is also used to help prevent the cancer from returning. Some breast cancers are made to grow faster by a natural hormone called estrogen. Exemestane decreases the amount of estrogen the body makes and helps to slow or reverse the growth of these breast cancers.Exemestane is usually not used in women of childbearing age.
Exemestane Recommended Dose
The recommended dose of AROMASIN in early and advanced breast cancer is one 25 mg tablet once daily after a meal.
adjuvant treatment of postmenopausal women with estrogen-receptor positive early breast cancer who have received two to three years of tamoxifen and are switched to AROMASIN for completion of a total of five consecutive years of adjuvant hormonal therapy.
the treatment of advanced breast cancer in postmenopausal women whose disease has progressed following tamoxifen therapy.
Exemestane Aromasin Half-Life
According to literature, the half life is 25-27 hours, which means you can easily get away with taking this drug every other day or once a day.
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9/20/2019 1:02:00 PM
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Wholesale Price of Semaglutide Powder with Good Qu
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Wholesale Price of Semaglutide Powder with Good Quality CAS: 910463-68-2
Names:Semaglutide powder
CAS No.:910463-68-2
MF:C187H291N45O59
EINECS No.:N/M
Place of Origin: China (Mainland)
Type:Semaglutide
Grade Standard:Cosmetic Grade, Medicine Grade, Tech Grade
Purity:99%
Product Name:Semaglutide
Appearance:White powder
Grade:Pharmaceutical intermediates
Assay:99%
Shelf life:2 Years
Molecular Weight:4113.64
Water Content ( Karl Fischer ):≤ 5.0%
Storage::Store in cool & dry place
Source:synthetic
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9/20/2019 1:04:29 PM
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High Purity Peptides Semaglutide for Medical
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High Purity Peptides Semaglutide for Medical
Cardiovascular disease is the leading cause of death and complications in patients with type 2 diabetes.1 Recently, trials evaluating a sodium-glucose cotransporter 2 inhibitor (empagliflozin) and a glucagon-like peptide 1 (GLP-1) analogue (liraglutide) have shown improved cardiovascular outcomes in patients with type 2 diabetes who were at high risk for cardiovascular events.2,3
Semaglutide powder, a GLP-1 analogue with an extended half-life of approximately 1 week (which permits once-weekly subcutaneous administration),4 is currently in development but not yet approved for the treatment of type 2 diabetes. Regulatory guidance specifies the need to establish the cardiovascular safety of new therapies for type 2 diabetes in order to rule out excess cardiovascular risk.5 The preapproval Trial to Evaluate Cardiovascular and Other Long-term Outcomes with Semaglutide in Subjects with Type 2 Diabetes (SUSTAIN-6) was designed to assess the noninferiority of semaglutide as compared with placebo in terms of cardiovascular safety in patients with type 2 diabetes.
Trial Design and Oversight
We performed a randomized, double-blind, placebo-controlled, parallel-group trial at 230 sites in 20 countries. The trial protocol, available with the full text of this article at NEJM.org, was approved by the institutional review board and ethics committee at each participating center. All patients provided written informed consent.
Patients were randomized in a 1:1:1:1 ratio to receive either 0.5 mg or 1.0 mg of once-weekly subcutaneous semaglutide or volume-matched placebo, which maintained blinding within dose. The trial consisted of a planned observation period of 109 weeks for all patients (a 104-week treatment period with a 5-week follow-up period) in which patients who had prematurely discontinued a study treatment were also included.
The sponsor, Novo Nordisk, designed the study. Data were gathered by the site investigators, and the sponsor performed site monitoring, data collection, and data analysis. An independent data and safety monitoring committee performed ongoing surveillance and had access to all the data in an unblinded fashion.
All the authors had confidential access to the final trial results and actively contributed to manuscript preparation. A working group that included the first and last authors wrote the first draft of the manuscript, which was revised and approved by all the authors, who made the decision to submit the manuscript for publication. The authors assume responsibility for the accuracy and completeness of the data and vouch for the fidelity of the trial to the protocol. Editorial support was funded by the sponsor and provided by independent medical writers under the guidance of the authors.
Patients
Patients with type 2 diabetes and a glycated hemoglobin level of 7% or more were eligible if they had not been treated with an antihyperglycemic drug or had been treated with no more than two oral antihyperglycemic agents, with or without basal or premixed insulin. Key inclusion criteria were an age of 50 years or more with established cardiovascular disease (previous cardiovascular, cerebrovascular, or peripheral vascular disease), chronic heart failure (New York Heart Association class II or III), or chronic kidney disease of stage 3 or higher or an age of 60 years or more with at least one cardiovascular risk factor (as defined in Table S1 in the Supplementary Appendix, available at NEJM.org).
Key exclusion criteria included treatment with a dipeptidyl-peptidase 4 inhibitor within 30 days before screening or with a GLP-1-receptor agonist or insulin other than basal or premixed within 90 days before screening; a history of an acute coronary or cerebrovascular event within 90 days before randomization; planned revascularization of a coronary, carotid, or peripheral artery; or long-term dialysis.
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9/20/2019 1:06:37 PM
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Peptide Raw Powder Synthesis CAS 910463-68-2 Semag
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Peptide Raw Powder Synthesis CAS 910463-68-2 Semaglutide API
Semaglutide powder is a glucagon-like peptide-1 (GLP-1) analog and functions as a GLP-1 agonist. It is indicated as an adjunct to diet and exercise to improve glycemic control in adults with type 2 diabetes mellitus.
Limitations of Use
Semaglutide is not recommended as a first-line therapy for patients who have inadequate glycemic control on diet and exercise because of the uncertain relevance of rodent C-cell tumor findings to humans.
Semaglutide has not been studied in patients with a history of pancreatitis. Consider other antidiabetic therapies in patients with a history of pancreatitis.
Semaglutide is not a substitute for insulin. Semaglutide is not indicated for use in patients with type 1 diabetes mellitus or for the treatment of patients with diabetic ketoacidosis, as it would not be effective in these settings.
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9/20/2019 1:09:25 PM
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What is Ipamorelin? phcoker
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What is Ipamorelin? phcoker
Ipamorelin，Ipamorelin Reviews (170851-70-4) is a drug that stimulates your body to produce more natural growth hormones and help you to achieve your goals. The growth hormones (GH) are produced in the pituitary glands which sometimes can fail or produce the hormones in low quantities. Ipamorelin stimulates the production of growth hormones in two ways. First, the drug increases the natural GH releasing hormone which eventually leads to high levels of the growth hormone secretion.
Secondly, Ipamorelin suppresses the somatostatin hormone which inhibits the production of growth hormones in your body. Apart from limiting the somatostatin activities in your body, this drug removes all the barriers blocking the natural production of the growth hormone hence improving the growth hormone production rate.
Unlike GHRP-2 and GHRP-6, Ipamorelin does not affect the ghrelin levels in your body system. That means you will not experience any increase in your appetite which is a good thing especially for those using the product to help them lose body fats and maintain their body weight. Also, those who take Ipamorelin as an anti-aging product it helps them to keep fit and look younger. The fact that this drug, stimulates your body to produce growth hormones, it means that there is no closure of the GH natural production like is the case with the synthetic HGH administration.
Ipamorelin triggers production of growth hormones in a way that resembles the natural production method and leads to constant production of this essential hormone. Furthermore, the process means that the drug exposes you to minimal side effects as compared to other growth hormone stimulating supplements. Ipamorelin creates a very smooth pulse for the production of GH for a long time which causes GH elevation for about 3 hours after taking your dosage.
Increasing your growth hormones naturally sounds like a good idea, and most probably that’s what you are looking forward to achieving. However, the reality remains that use of supplements only triggers your body to produce more HGH to help you attain your goals. Accompanying Ipamorelin with proper diet and workout will play an essential role in helping you accomplish your goals.
When using this drug, you should understand that human bodies are different so don’t expect the exact results like the one your friend got after using Ipamorelin. For instance, athletes who work out regularly might experience better effects than overweight people who don’t even bother going for gym sessions. That means some factors will determine the kind of results you will get after using Ipamorelin such as your body composition, medical condition among others. Some of the results to expect from using this drug include improving your body muscle mass, gaining lean muscles and burning the excess body fats.
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9/20/2019 1:11:30 PM
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Is Ipamorelin for us?
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Is Ipamorelin for us?
Legally, Ipamorelin，Ipamorelin Reviews (170851-70-4) is not sold for human consumption but medical research. However, after the discovery that the drug could be useful if used in humans, people started using it, and many are now enjoying its benefits. Laws usually vary from one government to another, and we encourage you to confirm your country’s legal stand on this drug. But your doctor can help you purchase the drug or, you can also find it on different online platforms. No matter how easily you can access the medication, make sure your doctor guides you in the whole process to avoid incidences of adverse side effects.The Truth you need to know before using MK-2866(Ostarine)
This medication can be used by athletes, bodybuilders, and anybody else with low levels of growth hormone. The main Ipamorelin work is to stimulate the production of growth hormones in the body. Growth hormones affect the whole body, that means all parts of the body and tissues will eventually be subjected to growth. Scientists have also stated that the drug can help athletes and bodybuilders to develop quality lean muscles. Due to the drugs ability to influence growth in all body tissues, some people use the drug as an anti-aging supplement.
On the other hand, the growth hormone presence in the body increases the body metabolism which helps the athletes and bodybuilders to burn the excess body fats. In cutting and bulking cycles, the drug will help the athletes during the recovery stage where it allows tissues to repair themselves. Growth hormones play a vital role in the growth of tissues which makes Ipamorelin for bodybuilding demand to rise.
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9/20/2019 1:14:03 PM
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Ipamorelin Raw Peptide Powder for Body Growth Weig
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Ipamorelin Raw Peptide Powder for Body Growth Weight Loss With Top Quality
Ipamorelin，Ipamorelin Reviews is a fascinating new muscle building discovery that is getting a lot of attention in the bodybuilding world.It is a synthetic peptide that has powerful Growth Hormon releasing properties.And these GH releasing properties are what is of interest to athletes and bodybuilders since they can make a tremendous difference in the amount of muscle you can grow and how quickly you burn fat.
Ipamorelin is a penta-peptide.(Aib-His-D-2-Nal-D- Phe-Lys-NH2) And, the strength it displays may very well make regular old Growth Hormon (GH) obsolete.But what athletes and bodybuilders really want to know is what is this wonder peptide capable of doing, how is it used, and how does it compare to the other GHRP peptides?
Athletes are taking Ipamorelin in a 200mcg -300mcg dosage, two or three times daily, using a tiny needle to inject.They usually start with the lower dose since side effects can include headaches or what feels like a head-rush.Ipamorelin can be taken at anytime but taking it about 30-45 minutes before a workout would seem ideal because of the pulse in Growth Hormon (GH) it creates allowing for maximum growth.
Studies on the effects of Ipamorelin on bone growth, body weight, and GH release showed some interesting conclusions.In one experiment, various doses were administered over the course of 15 days to test the group's reactions.
There was a distinct and dose-dependent effect on body weight gain however, the treatment group did not show a change in total levels.Nor did the treatment group produce serum markers of bone development.For example, the number of cells in the wide portion of the tibia (the shinbone) did not change significantly.This is a good thing because it suggests muscle growth with less potential for deformity of bone or cartilage.
The reaction of the pituitary to an aggressive i.V.Dose of Ipamorelin showed that plasma GH levels were notably reduced whereas they were unchanged after a comparable dose of GHRH.This is actually a good thing as it suggests that Ipamorelin may not decrease your body's natural GH production - further demonstrating that Ipamorelin is a selective GH releaser.
Ipamorelin does not induce hunger making it advantageous to those on a restricted calorie diet.And obviously, Ipamorelin's side-effects are enhanced when combined with since they too influence Growth Hormon/ release and production.
Application :
Ipamorelin is an interesting peptide taken 300mcg twice daily or you could lower the dose for 3 times daily, side effects are head rushs, I would recommend taking this 30 minutes before workout ,with gear, Ipamorelin is a new and potent synthetic pentapeptide which has distinct and specific (GH)-releasing properties. With the objective of investigating the effects on longitudinal bone growth rate , body weight , and GH release, Ipamorelin in different doses (0, 18, 90 and 450 μg/day) was injected three times daily for 15 days to test subjects, After intravital Tetracycline labelling on days 0, 6, and 13, LGR was determined by measuring the distance between the respective fluorescent bands in the proximal tibia metaphysis. Ipamorelin dose-dependently increased LGR from 42 μm/day in the vehicle group to 44, 50, and 52 μm/day in the treatment groups . There was also a pronounced and dose-dependent effect on body weight gain.
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9/20/2019 1:15:35 PM
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Semaglutide Reviews phcoker
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Semaglutide Reviews phcoker
Many people around the globe are using Semaglutide Reviews for its safety and efficacy in treating many conditions. It has been in the market for quite some time and everyone who has used it can attest that it isn’t an average drug. In this article, you will get to read some of our client’s feedback regarding Semaglutide use. Once you read them, you can tell the likeliness of this drug working for you. You’ll notice that Semaglutide reviews are numerous and in all, it has proven to be effective. Here are some of the Semaglutide reviews we have gotten from clients who buy Semaglutide from us.
Bai says, “When I turned thirty last year, I looked myself in the mirror and couldn’t believe that the person looking back right at me was myself. I looked old, tired and almost all my clothes couldn’t fit me. I decided to start my journey to weight loss. Where could I begin? I sought information about weight loss online and came across Semaglutide that seemed to have many positive reviews. I started doing Semaglutide research and decided to buy it from Phcoker.com. Ever since I ordered the drug from them, my body is becoming smaller and more appealing. I am no longer the foodie I was, and I now have less appetite and food cravings. For the last three months, I have lost nine kilograms. Other than having a healthy weight, all my fashionable clothes can now perfectly fit me, and they have never looked this good on me. Anyone struggling with weight should use this. You will love it.”
Chen says, “In the past, I thought that Type 2 Diabetes only occurs to those who had advanced in age until I got diagnosed when I was twenty-three. I felt low and couldn’t imagine that I was going to lose my toes to this monster disease. I tried making positive lifestyle changes in a bid to lose weight. It included getting a nutritionist whom I worked with closely and following a fitness regimen too. All these didn’t seem to make much change in my life, and my doctor kept telling me that I was prone to suffer from stroke and heart attack. It affected me so much physiologically, and I remember almost passing out during a meeting with my workmates. My colleagues got so concerned, and one of them told me aboutSemaglutide as a Diabetes medication. With no many options, I decided to give it a try, and I can confidently say that it has greatly helped me. Semaglutide use has significantly reduced the thirst and tiredness I used to feel. It has been two months, and my diabetes is now under control. Together with healthier eating and exercise, the Semaglutide injection has helped me live a normal life. Thank you Semaglutide.” FDA Approved Lorcaserin HCL For The Treatment Of Obesity
Tahiya says “If you are very keen on service providers you will notice that most of them do not give good customer service. I love feeling appreciated as a customer, and the first thing that comes to my mind when dealing with a service provider is the way they are treating me. I have recommended and continue to ask anyone in need of Semaglutide or the other drug to buy it from Phcoker. It is a fantastic site that delivers beyond one’s expectation. For the couple of times that I have bought from them, I have received my package on time. Besides, they are not too pricey, and their products are of high quality. Place your order with this customer-oriented site, and I can assure you that you will never look for any other Semaglutide supplier.”
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9/20/2019 1:17:50 PM
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Analysis Shows Oral Semaglutide Beats Empagliflozi
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Analysis Shows Oral Semaglutide Beats Empagliflozin for Reducing Blood Sugar
An analysis of phase 3 trial data for the investigational type 2 diabetes (T2D) drug oral Semaglutide Reviews shows the glucagon-like peptide 1 (GLP-1) receptor agonist does a better job reducing blood sugar than empagliflozin, a leading sodium glucose co-transporter 2 (SGLT2) inhibitor and the first T2D drug shown to offer cardiovascular benefits.
Other phase 3 results presented Saturday at the 79th Scientific Sessions of the American Diabetes Association (ADA) in San Francisco, California, show that oral semaglutide would produce more weight loss than liraglutide, the daily injectable GLP-1 receptor agonist sold as Victoza. Novo Nordisk makes both products.
In March, Novo Nordisk filed a new drug application for oral semaglutide, and also sought cardiovascular indications for both the oral and injectable form of the drug. FDA approved the once-weekly injectable formulation of semaglutide, sold as Ozempic, in December 2017. Cardiovascular results for oral semaglutide will be presented Tuesday at ADA and are among the most anticipated results of the meeting.
In a statement, Novo Nordisk said results from PIONEER 2, comparing oral semaglutide and empagliflozin, and PIONEER 4, comparing oral semaglutide to liraglutide, are based on the secondary statistical approach. The approach, the statement said, “is known as the trial product estimand and is used to assess the effect of oral semaglutide, assuming all patients remained on trial product and did not use rescue medication.”
Results for PIONEER 2 show:
Oral semaglutide produced statistically significant reductions in glycated hemoglobin (A1C) compared with empagliflozin, which is sold by Eli Lilly and Boehringer Ingelheim as Jardiance. Results at 26 weeks showed that oral semaglutide produced an A1C reduction of 1.4% compared with 0.9% for empagliflozin; the results were sustained at 52 weeks, with A1C reductions of 1.3% vs 0.8%, respectively.
More patients taking oral semaglutide achieved an A1C <7.0% than with empagliflozin.
PIONEER 2 also showed that oral semaglutide demonstrated weight loss of 4.2 kg compared with 3.8 kg for empagliflozin at 26 weeks. A statistically significant difference in weight loss was seen at 52 weeks: 4.7 kg for oral semaglutide vs 3.8 kg for empagliflozin.
Results for PIONEER 4 show:
Oral semaglutide produced statistically significant reductions in A1C compared with both liraglutide and placebo, at both 26 and 52 weeks. A1C reductions at 26 weeks were 1.3% for oral semaglutide, 1.1% for liraglutide and 0.1% for; at 52 weeks, A1C reductions were 1.2% for oral semaglutide and 0.9% for liraglutide, while placebo showed a 0.2% increase in A1C.
Oral semaglutide demonstrated statistically significant weight loss compared with both liraglutide and placebo, at both 26 and 52 weeks. Weight loss at 26 weeks was 4.7 kg for oral semaglutide, 3.2 kg for liraglutide and 0.7 kg for placebo; at 52 weeks, reductions were 5.0 kg for oral semaglutide, 3.1 kg for liraglutide and 1.2 kg for placebo at 52 weeks.
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9/20/2019 1:19:54 PM
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Raw GHRP-6 powder (87616-84-0)
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Raw GHRP-6 powder (87616-84-0)
GHRP-6 powder,GHRP 6 powder is a synthetic, growth hormone releasing hexapeptide, made of six amino acids. This peptide is one of many synthetic met-enkephalin analogs that include D-amino acids developed for growth hormone releasing properties.As well as promoting fat loss and muscle building it also appears to have a significant effect in decreasing inflammation and aiding recovery from injury.
Anecdotally, Raw GHRP-6 powder is considered an effective peptide with users reporting much greater fat loss, some muscle gain, and much reduced injury times. Combining the Raw GHRP-6 powder with anabolic steroids will yield very satisfying results, or alternatively it can offer an excellent choice during PCT and as a bridge to the next cycle.
Product Name Raw GHRP-6 powder
Chemical Name Raw GHRP-6 powder Acetate; UNII-4H7N4I6X6A; Growth hormone releasing peptide
Sequence His-DTrp-Ala-Trp-DPhe-Lys-NH2
Brand Name Raw GHRP-6 powder
Drug Class Peptide
CAS Number 87616-84-0
InChIKey WZHKXNSOCOQYQX-FUAFALNISA-N
Molecular Formula C46H56N12O6
Molecular Weight 873.032 g/mol
Monoisotopic Mass 873.01
Melting Point N/A
Freezing Point N/A
Biological Half-Life About 30 min only, causing the GH concentration to reach its peak value around 15 min after administration.
Color Sterile Filtered White lyophilized (freeze-dried) powder.
Solubility It is recommended to reconstitute the lyophilized Raw GHRP-6 powder in sterile 18M Omega -cm H2O not less than 100 ug/ml, which can then be further diluted to other aqueous solutions.
Storage Temperature Lyophilized Growth Hormone Releasing Peptide-6 although stable at room temperature for 3 weeks, should be stored desiccated below -18C. Upon reconstitution Raw GHRP-6 powder should be stored at 4C between 2-7 days and for future use below -18C. For long term storage it is recommended to add a carrier protein (0. 1% HSA or BSA). Please prevent freeze-thaw cycles.
Application Promoting fat loss and muscle building, have a significant effect in decreasing inflammation and aiding recovery from injury.
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